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Update of hematopoietic cell transplantation for sickle cell disease

key information

source: Current Opinion in Hematology

year: 2015

authors: Walters MC

summary/abstract:

PURPOSE OF REVIEW:
Hematopoietic cell transplantation (HCT) is a curative therapy for sickle cell disease (SCD) that is utilized very rarely because of limited allogeneic donor availability, limited healthcare resources needed to expand the treatment to regions in the world where most affected individuals reside, and by a view among SCD experts that HCT lacks the evidential rigor with short and long-term toxicity profiles that together might support its broader application.

RECENT FINDINGS:
In this update, recent advances focused on donor selection, reduced toxicity preparation for HCT, and treatment of young adults will be presented. The current status of conventional bone marrow transplantation with a human leukocyte antigen-identical sibling donor is summarized.

SUMMARY:
HCT for SCD is curative in almost all children who have a human leukocyte antigen-matched sibling donor. The future of this therapy will hinge on expanding the number of individuals who might be treated.

organization: UCSF Benioff Children's Hospital, Oakland

DOI: 10.1097/MOH.0000000000000136

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