Google
Trusted Resources: News & Events
Latest announcements and gatherings
University researchers develop more complete model of sickle cell
University researchers have developed computational methods using a supercomputer that enables them to dive deep inside sickle cells and analyze their molecular characteristics. By modeling the processes responsible for sickle cell formation, the team will be able to explore possible treatments for the disease.
Sickle cell anemia is caused by a genetic mutation that makes normally concave, round red blood cells become stiff and misshapen, said George Karniadakis, professor of applied mathematics. Sickle cell was identified as the first molecular disease by Nobel laureate Linus Pauling in 1949.
Pauling’s initial characterization was based on the behavior of hemoglobin, a molecule normally distributed evenly throughout the red blood cell. In an infected individual, the molecule “will self-assemble into a fiber, and this fiber will push the red blood cell into a sickle shape,” said Lu Lu GS, the study’s first author and a member of Karniadakis’ research group.
+myBinderRelated Content
-
Drugs for preventing red blood cell dehydration in people with sickle cell diseaseBACKGROUND: Sickle cell disease is an i...
-
Association of circulating transcriptomic profiles with mortality in sickle cell diseaseSickle cell disease (SCD) complications ...
-
Corinna Schultz, MD: Does Sickle Cell Trait Get Discussed?According to data presented tonight at t...
-
Marina Jerebtsova, PhDDr Marina Jerebtsova is an assistant pro...
-
Healthy red blood cells owe their shape to muscle-like structuresRed blood cells are on a wild ride. As t...
-
Small chips, big impact: MSU researcher studies cardiovascular, sickle cell diseaseA Mississippi State University researche...
-
Computer models provide new understanding of sickle cell diseaseComputer models developed by Brown Unive...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.