Google
Trusted Resources: People & Places
Healthcare providers, researchers, and advocates
Osheiza Abdulmalik, PhD
Researcher Research Associate II
Perelman School of Medicine
University of Pennsylvania
Rivella Lab
3615 Civic Center Blvd
Room 316B
Abramson Research Center
Philadelphia, Pennsylvania, United States
Dr. Abdulmalik’s research interests broadly encompass the hemoglobinopathies and red blood cell disorders, with particular focus on sickle cell disease and beta-thalassemia. Though both disorders are consequences of simple genetic mutations, the implications of these mutations are inherently complex, and include significant morbidities, lifelong challenges, reduced quality of life, and early mortality in patients; as well as substantial healthcare burden on families, caregivers, and society in general.
Dr. Abdulmalik’s current research focuses on three modalities of countering disease pathophysiology. The first approach, in tandem with a multidisciplinary team of collaborators, utilizes medicinal chemistry and structural biology to design novel drugs that block the primary pathophysiology of sickle cell disease, i.e., the polymerization of sickle hemoglobin.
Representative Publications:
Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation
+myBinderRelated Content
-
2019 Cure Sickle Cell Initiative Annual Forum: Accelerating Scientific PrioritiesTuesday, November 19 - Thursday, Novembe...
-
Roald Dahl’s Marvellous Children’s Charity “Everyone’s Business” campaignhttps://www.youtube.com/watch?v=VqdP3Sxa...
-
Dr. Nina AndersonDr. Nina Anderson, completed her doctora...
-
University Hospitals Seidman Cancer CenterUniversity Hospitals Seidman Cancer Cent...
-
Steven Hardy, PhDSteven Hardy, Ph.D. is the Director of P...
-
Factors influencing utilization of hospital services by adult sickle cell disease patients: a systematic reviewBACKGROUND: Painful vaso-occlusive crisi...
-
Dental Health in Children with Sickle Cell DiseaseWhat is Sickle Cell Disease? Sickle Cel...
