Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy
source: American Journal of Hematology
year: 2015
authors: Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, Fuh B, King A, Meier ER, Casella J, DeBaun MR, Panepinto JA
summary/abstract:The completion of the Multicenter Silent Infarct Transfusion Trial demonstrated that children with pre-existing silent cerebral infarct and sickle cell anemia (SCA) who received regular blood transfusion therapy had a 58% relative risk reduction of infarct recurrence when compared to observation. However, the total benefit of blood transfusion therapy, as assessed by the parents, was not measured against the burden of monthly blood transfusion therapy. In this planned ancillary study, we tested the hypothesis that a patient centered outcome, health-related quality of life (HRQL), would be greater in participants randomly assigned to the blood transfusion therapy group than the observation group. A total of 89% (175 of 196) of the randomly allocated participants had evaluable entry and exit HRQL evaluations. The increase in Change in Health, measured as the child’s health being better, was significantly greater for the transfusion group than the observation group (difference estimate = -0.54, P ≤ 0.001). This study provides the first evidence that children with SCA who received regular blood transfusion therapy felt better and had better overall HRQL than those who did not receive transfusion therapy.
organization: Medical College of Wisconsin/Children's Research Institute of the Children's Hospital of Wisconsin, MilwaukeeDOI: 10.1002/ajh.23877
read more full text
+myBinderRelated Content
-
A New Era in Sickle Cell Disease Treatment – 2nd Biennial pediatric-adults regional sickle cell disease confer...This biennial educational conference foc...
-
Alexis Thompson, MD, MPHDr. Alexis Thompson is currently the Hem...
-
Susan P. Perrine, MDHer research is dedicated to identifying...
-
Sickle Cell Disease and Cold Weather: Dos and Don’tsIn the United States today, one of every...
-
Folate supplementation in people with sickle cell diseaseBACKGROUND: Sickle cell disease is a gr...
-
TLC’s Tionne ‘T-Boz’ Watkins on Living With Sickle Cell DiseaseSinger Tionne "T-Boz" Watkins is opening...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.