Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle cell disease
source: The Lancet
year: 2017
authors: Ware RE, de Montalembert M, Tshilolo L, Abboud MR
summary/abstract:Sickle cell disease is a common and life-threatening haematological disorder that affects millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in small vessels, and this vaso-occlusion leads to distal tissue ischaemia and inflammation, with symptoms defining the acute painful sickle-cell crisis. Repeated sickling and ongoing haemolytic anaemia, even when subclinical, lead to parenchymal injury and chronic organ damage, causing substantial morbidity and early mortality. Currently available treatments are limited to transfusions and hydroxycarbamide, although stem cell transplantation might be a potentially curative therapy. Several new therapeutic options are in development, including gene therapy and gene editing. Recent advances include systematic universal screening for stroke risk, improved management of iron overload using oral chelators and non-invasive MRI measurements, and point-of-care diagnostic devices. Controversies include the role of haemolysis in sickle cell disease pathophysiology, optimal management of pregnancy, and strategies to prevent cerebrovascular disease.
organization: Cincinnati Children's Hospital Medical Center; Hopital Necker, LABEX GR-Ex, Paris; Centre Hospitalier Monkole, Kinshasa; American University of BeirutDOI: 10.1016/S0140-6736(17)30193-9
read more full text
+myBinderRelated Content
-
Environmental, genetic factors may predict longevity in sickle cell diseaseA case series of individuals with sickle...
-
Immunoglobulin G Responses Against Falciparum Malaria Specific Antigens are Higher in Children with Homozygous Sickl...Background: High Immunoglobulin G (IgG)...
-
Screening for sickle cell and beta thalassaemiaSickle cell and beta thalassaemi...
-
Sickle Cell Stories: Office of Minority Health, U.S. Department of Health and Human Serviceshttps://www.youtube.com/watch?v=HFojyaji...
-
Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army SoldiersBACKGROUND: Studies have suggested that...
-
Sickle Cell Disease: All you Need to KnowSickle cell disease (SCD) is an inherite...
-
National Sickle Cell Disease Poll of African Americans Dispels Long-Held ViewsPfizer Inc. (NYSE:PFE), the National New...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.