Or register here
Global Search

Trusted Resources: Evidence & Education

Scientific literature and patient education texts

Back to Evidence & Education / Scientific Articles

Type 2 Diabetes in Adults With Sickle Cell Disease: Can we Dive Deeper? Response to Skinner et al

key information

source: British Journal of Haematology

year: 2019

authors: Jifang Zhou, Jin Han, Edith A. Nutescu, William L. Galanter, Surrey M. Walton, Victor R. Gordeuk, Santosh L. Saraf, Gregory S. Calip

summary/abstract:

We read with interest the letter from Skinner, Nader and Connes and their comments on our recently published study on the burden of type 2 diabetes (T2D) in patients with sickle cell disease (SCD). The authors call attention to variation in T2D risk across patients with different SCD genotypes. Despite the fact that SCD is caused by single gene disorders, patients with SCD demonstrate a complex spectrum of complications and phenotypic heterogeneity that can be partially explained by the variability of fetal haemoglobin levels and co‐inheritance of alpha thalassaemia. It is plausible to speculate that SCD patients of different genetic foundation could present distinct pathophysiology features, including lipid profile and anthropometrics, which in turn could influence the likelihood of being diagnosed with T2D.

To answer the questions raised by Dr. Skinner and colleagues, we must acknowledge the inherent limitations of administrative health databases in performing studies of disease burden. Herein we describe the challenges of further exploration of these currently available data and the necessary methodological considerations for such epidemiological studies, particularly possible information and selection biases.

organization: University of Illinois at Chicago, USA; Fred Hutchinson Cancer Research Center, USA

DOI: 10.1111/bjh.15949

read more

Related Content

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

© 2025 rareLife solutions Inc.

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close